The effect of glutathion on the reaction of cis-and trans-diamminedichloroplatinum(II) with DNA.
نویسنده
چکیده
Differential pulse polarography study was used to investigate the influence of glutathion on cis- and trans-DDP induced alterations of DNA structure. Though the applied concentration of glutathion has no effect on the reaction on DNA with cis-DDP, it greatly modifies the reaction with trans isomer. This may be an important reason for the ineffectiveness of the trans-DDP as an antitumor drug.
منابع مشابه
Platinum incorporation and differential effects of cis- and trans-diamminedichloroplatinum(II) on the growth of mouse leukemia P388/D1.
The parallel effects of cis-diamminedichloroplatinum(II) (1 microM) or trans-diamminedichloroplatinum(II) (20 microM) on the growth of mouse leukemia P388/D1 in culture, on the cellular content of protein/DNA, on the average cell volume, and on the distribution in different phases of the cell cycle were measured over a period of 70 h and compared with the amount of platinum residing in the cell...
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ورودعنوان ژورنال:
- Zeitschrift fur Naturforschung. C, Journal of biosciences
دوره 45 11-12 شماره
صفحات -
تاریخ انتشار 1990